sarcoidosis

non-caseating granulomatous disease

unknown etiology
young adults, blacks > whites
prognosis usually good
may affect any organ
chest most often involved
diffuse pulmonary infiltrate, may resolve or progress to fibrosis
- HRCT:
  - mediastinal adenopathy
  - early = septal thickening, peribronchovascular nodules, alveolitis, ground-glass opacity
  - late = traction bronchiectasis, fibrosis, honeycombing
skeleton involved in 10%
Dx: bronchial/transbronchial biopsy (60-95% diagnostic), liver or scalene bx, Kveim test

Charles E. Kahn, Jr., MD - 2 February 1995
Last updated: 1 September 2006