CHORUS

Collaborative Hypertext of Radiology

Nervous system

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Hallervorden-Spatz disease

• extrapyramidal dysfunction (parkonsonism)
• autosomal recessive inhertance

CT findings

• high-signal lesions in globus pallidus bilaterally

MRI findings (T2-weighted spin-echo)

• hypointensity in globus pallidus (iron accumulation)
• small area of hyperintensity in internal segment (so-called "eye of the tiger" sign) corresponding to area of gliosis and vacuolation

Related CHORUS documents: parkinsonism brain iron Wilson disease Huntington disease (chorea-athetosis) progressive supranuclear palsy (Steele-Richardson-Olszewski syndome) acanthosis nigricans