Alexander disease

dysmyelinating disease
• rare, sporadic
• usually presents in 1st year
• megalencephaly: gradual enlargement of head
• retardation, convulsion, spasticity

CT findings:
• decreased density of white matter
• frontal lobe predominance
• +/- dilated lateral ventricles

© 2002, C.E. Kahn, Jr.
2002-04-18