brain iron

• Normal
  • Infant: NONE
  • Adult: globus pallidum, substantia nigra, red nucleus, dentate nucleus
  • Aging: (adult) + putamen
• Degenerative disease
  • Parkinson disease: putamen, SN compacta
  • Huntington disease: caudate, putamen
  • Alzheimer disease: cerebral cortex
  • Hallervorden-Spatz disease
• MS: thalamus, putamen
• Others
  • AVM: malformation + rim
  • Bleed: rim macrophages
  • Hemorrhagic CVA: gyral / basal ganglia

MRI: low T1 + T2 signal, blooming on gradient echo

© 2002, C.E. Kahn, Jr.
2002-04-18