Castleman disease

• angiofollicular lymph node hyperplasia

• benign lymphoid hyperplasia
• massively enlarged lymph nodes
• mediastinum most common; rarely in mesentery
• age < 30 yrs

• types: hyaline vascular (90%)
  • asymptomatic
  • vascular proliferation + hyalinization

• plasma cell (10%)
  • fever
  • anemia
  • increased sed rate, increased IgG

© 2002, C.E. Kahn, Jr.
2002-04-18