dysmyelinating disease

abnormal formation or maintenance of myelin
enzymatic defect: infants + young kids

metachromatic leukodystrophy
- aryl sulfatase A deficiency
- CT: decreased density throughout white matter
adrenoleukodystrophy
- males: X-linked recessive
- CT: decreased density in POSTERIOR white matter
other leukodystrophies
- Canavan, Krabbe, Alexander, Pelizaeus-Merzbacher, Cockayne

see also: