MEN-1 (Wermer) syndrome

multiple endrocrine neoplasia (MEN) syndrome
"three P's"

pituitary adenoma
- 65% ==> Cushing's, acromegaly, prolactinoma
parathyroid hyperplasia / adenoma
- 88% ==> hyper-PTH
pancreatic islet-cell tumor
- gastrinoma (Zollinger-Ellison syndrome) most common
- 50% of Z-E ==> MEN-1

inconstant features: bronchial/intestinal carcinoid, thyroid adenoma, adrenal cortical tumor, lipoma, thymoma