MEN-2 (Sipple) syndrome

multiple endocrine neoplasia (MEN) syndrome
• medullary thyroid Ca
  • usually multifocal; mets --> local nodes, lung, liver
  • usually calcify in liver

• pheochromocytoma
  • almost always bilateral

• parathyroid hyperplasia
  • may be 2' to calcitonin secreted by medullary thyroid Ca

• adrenal cortical hyperplasia

© 2002, C.E. Kahn, Jr.
2002-04-18