pancreatic islet-cell tumors

insulinoma (beta-cell)
- usually solitary, 85% benign
gastrinoma
- small, slow-growing, multiple, 60% malignant
- Zollinger-Ellison syndrome: mult. intractable ulcers
VIPoma
- vasoactive intestinal peptide (VIP)
- WDHA syndrome: watery diarrhea, hypokalemia, achlorhydria
- Verner-Morrison syndrome
glucagonoma
- hyperglycemia, migratory necrolytic erythema
APUDomas, associated with MEN-1