Peutz-Jeghers syndrome

• autosomal dominant (50% sporadic)
• hamartomas
  • primarily of SB
  • also: stomach, colon
  • occasionally of urinary or respiratory tract
• mucocutaneous hyperpigmentation

• increased risk of GI + non-GI tumors! (NEJM 1988)

© 2002, C.E. Kahn, Jr.
2002-04-18