Werner syndrome
"cataract in connection with scleroderma"
- rare; unknown etiology
- M = F
- premature aging, short stature
- thin, atrophic extremities
- generalized osteoporosis
- accelerated atherosclerosis (calcification of arteries, heart valves)
- beaked nose
- multiple infections (incl. osteomyelitis)
- scleroderma-like skin changes
- increased incidence of malignancy: GI tract, lung, kidney, ovary, breast
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© 2002, C.E. Kahn, Jr.
2002-04-18