hepatoblastoma

• 3rd most common intra-abd malignancy (after neuroblastoma + Wilms tumor)

• kids: 50% before 18 m/o, almost all < 3 y/o

• right lobe (75%), both lobes or multicentric (33%)
• mets at dx in 10% ==> local invasion, regional nodes, lungs

• increased aFP in 67-90%
• liver enzymes usually normal

• hemihypertrophy
• macroglossia
• sexual precocity

© 2002, C.E. Kahn, Jr.
2002-04-18