Crohn disease: extraintestinal manifestations

• fatty liver
• gallstones (28-34%)
  • risk 3-5X higher than expected
  • secondary to malabsorption of bile salts in terminal ileum
  • correlation with length of diseased ileum and duration of disease
• sclerosing cholangitis
• bile duct carcinoma
• amyloidosis
• urolithiasis: oxalate/uric acid stones
• migratory arthritis (5-20%), sacroilitis, ankylosing spondylitis
• erythema nodosum, uveitis

© 2002, C.E. Kahn, Jr.
2002-04-18