colon carcinoma

• risk factors:
  • colonic adenoma
    • 93% of colorectal CA arises from adenomatous polyps
    • 5% of adenomas 5mm in size develop into Ca
  • family history + polyposis syndromes
  • chronic ulcerative colitis
  • prominent lymphoid follicular pattern
  • history of endometrial + breast Ca

• mets: liver (25%); retroperitoneal/mesenteric nodes (15%); hydronephrosis (13%); adrenal (10%); ovary; psoas muscle; ascites

• risk of:
  • 1% for synchronous colon Ca
  • 3% for metachronous colon CA
  • 3.8% for extracolonic malignancy
• Dukes A: bowel wall; B: serosa/mesentery; C: lymph nodes; D: mets

© 2002, C.E. Kahn, Jr.
2002-04-18