histoplasmosis

• mostly subclinical
• multiple nodules (3-4mm) changing into punctate calcifications
• histoplasmoma (non-calcifying nodules <3mm)
• "target lesion" (central calcification) is pathognomonic
• hilar/mediatinal adenopathy ("popcorn" calcification)

• mostly in COPD patients
• upper lobe cavitation with fibrosis (similar to TB)
• sclerosing mediastinitis with obstruction of SVC, pulmonary arteries and veins, esophagus, and constrictive pericarditis

• infants and elderly; rapidly fatal
• may show pulmonary consolidation
• hilar/mediatinal adenopathy
• hepatosplenomegaly (splenic calcifications in 40%)

© 2002, C.E. Kahn, Jr.
2002-04-18