acute lymphocytic leukemia (ALL)

• 95% of cases of leukemia in children

• bone changes in 50-70% of kids (vs. 10% in adults); seen as early as 1 month after onset of symptoms
• wrists and knees most commonly affected

• bony defects:
  1. metaphyseal radiolucent bands!
     (similar findings in scurvy, JRA, syphilis)
  2. osteolytic lesions
  3. periosteal reaction
  4. osteosclerosis

© 2002, C.E. Kahn, Jr.
2002-04-18